The inflammasome is a multiprotein intracellular complex that detects pathogenic microorganisms and sterile stressors, and that activates the highly pro-inflammatory cytokines interleukin-1b (IL ...
"Buprenorphine is essentially triggering sterile inflammation through this innate immune receptor that classically recognizes infections," Abrahams says. The NLRP3 inflammasome is a protein ...
Inflammasomes are huge, multi-protein complexes inside cells that spark inflammation when they sense danger ... and the mechanisms behind how some of them form under so-called sterile conditions has ...